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Metronidazole has demonstrated evidence of mutagenic exercise in numerous in vitro bacterial assay systems. In addition, a dose-related rise in the frequency of micronuclei was noticed in mice just after intraperitoneal injections. A rise in chromosomal aberrations in peripheral blood lymphocytes was described in people with Crohn’s illness who were being taken care of with 200 to 1200 mg/working day of metronidazole for 1 to 24 months.

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